School of Medicine

Wayne State University School of Medicine

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Russell Finley
Title
Professor
Phone
313-577-7845
Profile

Our research is broadly aimed at understanding how regulatory networks control biological processes, such as the cell division cycle. We identify and characterize networks of interacting genes and proteins using high throughput technologies, including the yeast two-hybrid system and RNAi screens. The interaction maps that we generate from these studies form the foundation for discovering and understanding cellular regulatory pathways. A second theme of our research is directed at understanding the molecular mechanisms that control cell division. For these studies, we are using the genetically tractable model organism, Drosophila (the fruit fly) to study gene networks centered on two novel conserved cyclin proteins (named Cyclin Y and Cyclin J). Cyclin proteins are regulators of cyclin-dependent kinases (Cdks), which are highly conserved S/T protein kinases that control the cell division cycle in all eukaryotes.

Labatory Website

Graduate
Ph.D., 1990, SUNY Upstate Medical University
Postdoctoral Fellow, 1990-1995, Harvard Medical School and Massachusetts General Hospital
Interests

Research Areas: Regulatory networks that control cell proliferation; cell cycle regulation during development in Drosophila; high throughput technologies to study biological networks.

Publications
  • Atikukke*, G., Albosta*, P., Zhang, H., and Finley, Jr., R.L., A role for Drosophila Cyclin J in oogenesis revealed by genetic interactions with the piRNA pathway. Mechanisms of Development 133:64-76, 2014. [PMID: 24946235]
  • Murali, T., Pacifico, S., and Finley, Jr., R.L. Integrating the interactome and the transcriptome of Drosophila. BMC Bioinformatics, 15:177. 2014. DOI: 10.1186/1471-2105-15-177. [PMID: 24913703]Mairiang D, Zhang H, Sodja A, Murali T, Suriyaphol P, Malasit P, Limjindaporn T, Finley RL Jr. Identification of new protein interactions between dengue fever virus and its hosts, human and mosquito. PLoS One.
  • 2013;8(1):e53535. doi: 10.1371/journal.pone.0053535. Epub 2013 Jan 11. [PubMed PMID: 23326450; PubMed Central PMCID: PMC3543448.]
  • Yu J, Murali T, Finley RL Jr. Assigning confidence scores to protein-protein interactions. Methods Mol Biol. 2012;812:161-74. doi: 10.1007/978-1-61779-455-1_9. PubMed PMID: 22218859.
  • Guest, S.T., Yu, J., Liu, D., Hines, J.A., Kashat, M.A., and Finley, Jr., R.L. A protein network-guided screen for cell cycle regulators in Drosophila. BMC Systems Biology 5:65, 1-16, 2011. [PMID: 21548953] (PMCID: PMC3113730)
  • Murali*, T., Pacifico, S., Yu, J., Guest, S., Roberts, G.G., and Finley, Jr., R.L. DroID 2011: A comprehensive, integrated resource for protein, transcription factor, RNA, and gene interactions for Drosophila.  Nucleic Acids Research, D736-743, 29 Jan 2011. [PMID: 21036869] (PMCID: PMC3013689)
  • Liu*, D., and Finley, Jr., R.L. Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Genetics, 184: 1025-1035, 2010. [PMID: 20100936] (PMCID: PMC2865905)
  • Schwartz, A.S., Yu, J., Gardenour, K.R., Finley, Jr., R.L., and Ideker, T. Cost effective strategies for mapping the interactome. Nature Methods, 6: 55-61, 2009. (PMCID: PMC2613168)